Sodium Hydroxide → HCID 15096390, compound

Reaction equation

[OH:1][CH2:2][C:3]([NH:5][CH:6]([C:12]([O:14]CC)=[O:13])[C:7]([O:9]CC)=[O:8])=[O:4].[OH-].[Na+:18]>>[OH:1][CH2:2][C:3]([NH:5][CH:6]([C:12]([O-:14])=[O:13])[C:7]([O-:9])=[O:8])=[O:4].[Na+:18].[Na+:18]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 150963891,3-Diethyl 2-[(2-hydroxyacetyl)amino]propanedioate

Product 1

HCID 15096390HCID 15096390, compound

Procedure

Diethyl 2-[(hydroxyacetyl)amino]malonate (0.56 g) is dissolved in 1N aqueous sodium hydroxide (5 ml), and the mixture is reacted at room temperature for 10 hours, and thereafter, the reaction mixture is concentrated under reduced pressure. The residue is washed with methanol to give disodium 2-[(hydroxyacetyl)amino]malonate (0.51 g).

Workup

customthe mixture is reacted at room temperature for 10 hours
concentrationthe reaction mixture is concentrated under reduced pressure
washThe residue is washed with methanol

Sources & evidence

ORD record: ord-5ecdab6a188f4da69a6a1e8d3cec2ada
Source dataset: uspto-grants-1989_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04882447

Reaction notes

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