Iodoacetic Acid → Diethyl 2-[(iodoacetyl)amino]malonate

Reaction equation

[NH2:1][CH:2]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[I:13][CH2:14][C:15](O)=[O:16]>>[I:13][CH2:14][C:15]([NH:1][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:16]

Participants

Reactant 2

HCID 5240Iodoacetic Acid

HCID 81272Propanedioic acid, 2-amino-, 1,3-diethyl ester

Product 1

HCID 15096465Diethyl 2-[(iodoacetyl)amino]malonate

Procedure

Diethyl 2-aminomalonate and iodoacetic acid are treated in the same manner as described in Reference Example 1 to give diethyl 2-[(iodoacetyl)amino]malonate, m.p. 96°-98° C.

Sources & evidence

ORD record: ord-3014e318e731428a9a99bd718c921f77
Source dataset: uspto-grants-1989_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04882447

Reaction notes

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