3-Phenylprop-2-enenitrile → N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

HRID 1640432

Reaction equation

HRID 1640432 reaction equation
[C:1](#[N:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH2:17])[CH:13]=1.[CH3:18][S:19]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])=[O:20]>>[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH:17][C:3]2[CH:2]=[C:1]([N:25]3[CH2:26][CH2:27][N:22]([S:19]([CH3:18])(=[O:21])=[O:20])[CH2:23][CH2:24]3)[N:10]=[C:1]([CH:2]=[CH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:10]=2)[CH:13]=1

Participants

4

Reactant 3

HCID 746673-Phenylprop-2-enenitrileHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 7091611-(Methylsulfonyl)piperazine

Product 1

HCID 66738751N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

Procedure

Example 71 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials cinnamonitrile, 5-methyl-1H-pyrazole-3-amine, and 4-methylsulfonylpiperazine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.

Workup

  1. customExample 71 was synthesized via Scheme 6 according to the general scheme
  2. customprovided above with the

Sources & evidence

ORD record
ord-b45a4f3bcf5c402fb384ce43081c2e16
Source dataset
uspto-grants-2012_02
Patent number
US08114870B2

Linked notes

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