1H-Indazole-3-carbonyl chloride → N-((quinuclidin-4-yl)methyl)-1H-indazole-3-carboxamide
Reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([CH2:9][NH:10][C:11]([C:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[NH:15]C=3)=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[NH:22]1C2C(=CC=CC=2)C(C(Cl)=O)=N1>>[N:1]12[CH2:8][CH2:7][C:4]([CH2:9][NH:10][C:11]([C:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[NH:15][N:22]=3)=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2Participants
3
Procedure
N-((quinuclidin-4-yl)methyl)-1H-indazole-3-carboxamide was prepared in a similar manner to N-((quinuclidin-4-yl)methyl)-1H-indole-3-carboxamide, substituting 1H-indazole-3-carbonyl chloride as the electrophile. 1HNMR: 13.6 (bs, 1H); 9.65 (bs, 1H); 8.45 (t, 1H); 8.15 (d, 1H); 7.62 (d, 1H); 7.41 (t, 1H); 7.2 (t, 1H); 3.28 (m, 2H); 3.21 (m, 6H); 1.70 (m, 6H). MS (m/e): 285.
Sources & evidence
- ORD record
- ord-bea88cfc64a7497391dc3a2944a5a6a6
- Source dataset
- uspto-grants-2012_02