Benzo[d]isothiazole-3-carbonyl chloride → HCID 25234270, compound

Reaction equation

[N:1]12[CH2:8][CH2:7][C:4]([CH2:9][NH:10][C:11]([C:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)NC=3)=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[S:22]1C2C=CC=CC=2C(C(Cl)=O)=[N:23]1>>[N:1]12[CH2:8][CH2:7][C:4]([CH2:9][NH:10][C:11]([C:13]3[C:21]4[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=4[S:22][N:23]=3)=[O:12])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2

Participants

Reactant 2

HCID 15639471Benzo[d]isothiazole-3-carbonyl chloride

HCID 25210594N-((quinuclidin-4-yl)methyl)-1H-indole-3-carboxamide

Product 1

HCID 25234270HCID 25234270, compound

Procedure

N-(quinuclidin-4-ylmethyl)benzo[d]isothiazole-3-carboxamide was prepared in a similar manner to N-((quinuclidin-4-yl)methyl)-1H-indole-3-carboxamide, substituting benzo[d]isothiazole-3-carbonyl chloride as the electrophile.

Sources & evidence

ORD record: ord-6c606ebf8c674f9a9aa509a60e9003f4
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114891B2

Reaction notes

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