Sulfuric Acid → 1H-indazol-4-ol

HRID 16411

Reaction equation

HRID 16411 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5](N)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.S(=O)(=O)(O)[OH:12].[OH-].[Na+]>>[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([OH:12])[C:4]=2[CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 413085NoName_3327

Product 1

HCID 1357424501H-indazol-4-ol

Procedure

500 mg (375 mmol) of 1H-indazol-4-ylamine (prepared according to J. Chem. Soc. 1955, 2412, 2419) are stirred in 10% strength sulfuric acid at 180° C. in an autoclave at intrinsic pressure overnight. The reaction solution is cooled to room temperature and neutralized with 1N sodium hydroxide solution, and the salts are filtered off. The filtrate is concentrated to dryness.

Workup

  1. filtrationthe salts are filtered off
  2. concentrationThe filtrate is concentrated to dryness

Sources & evidence

ORD record
ord-3424705caf554a55a61da2572693309a
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Linked notes

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