HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 16425Generated: October 23, 2026
Hydrochloric Acid → 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile
https://huagongshe.com/en/reaction/16425
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile | HCID 240806 | — |
Reaction Steps
300 mg (1.83 mmol) of 2-amino-4,6-dichloropyrimidine and 216 mg (1.83 mmol) of 4-aminobenzonitrile are suspended in 6 ml of water. 180 μl of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. The precipitate is filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07737153B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-b294971d5690468ca48fed2a90495ae2 |
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| Source note | uspto-grants-2010_06 |
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