Acetohydrazide → N'-Acetyl-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide

HRID 1642833

Reaction equation

HRID 1642833 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=[O:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:29]([NH:32][NH2:33])(=[O:31])[CH3:30]>>[C:29]([NH:32][NH:33][C:26]([CH:11]1[CH2:12][CH:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:23])([F:25])[F:24])=[CH:17][CH:16]=2)[CH2:14][N:9]([C:7]([N:1]2[CH2:2][CH2:3][O:4][CH2:5][CH2:6]2)=[O:8])[CH2:10]1)=[O:27])(=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 14039AcetohydrazideHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002704N'-Acetyl-1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carbohydrazide

Procedure

100 mg (0.25 mmol) of the compound from Example 44A and 37 mg (0.50 mmol) of acetohydrazide were reacted according to the General Method 11A. Yield: 106 mg (93% of theory)

Sources & evidence

ORD record
ord-dc3b9a11119b4bda9b983b1690813904
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Linked notes

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