4,4-Difluoropiperidine hydrochloride → HCID 58002734, compound
Reaction equation
[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=4)[CH2:12][N:11]([C:26](OC4C=CC([N+]([O-])=O)=CC=4)=[O:27])[CH2:10]3)[O:6][N:5]=2)[CH2:3][CH2:2]1.Cl.[F:39][C:40]1([F:46])[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1>>[CH:1]1([C:4]2[N:8]=[C:7]([CH:9]3[CH2:14][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:24])([F:25])[F:23])=[CH:17][CH:16]=4)[CH2:12][N:11]([C:26]([N:43]4[CH2:44][CH2:45][C:40]([F:46])([F:39])[CH2:41][CH2:42]4)=[O:27])[CH2:10]3)[O:6][N:5]=2)[CH2:2][CH2:3]1Participants
3
Procedure
100 mg (0.19 mmol) of the compound from Example 176A and 91 mg (0.58 mmol) of 4,4-difluoropiperidine hydrochloride were reacted according to the General Method 6. Yield: 48 mg (50% of theory)
Sources & evidence
- ORD record
- ord-fcbb36bcc81e450eb5c54241f1641a1e
- Source dataset
- uspto-grants-2012_02