Ethambutol Hydrochloride → Ethambutol

HRID 1643530

Reaction equation

HRID 1643530 reaction equation
[CH3:1][CH2:2][C@H:3]([NH:6][CH2:7][CH2:8][NH:9][C@H:10]([CH2:13][OH:14])[CH2:11][CH3:12])[CH2:4][OH:5].Cl.Cl>C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>[CH3:12][CH2:11][C@H:10]([NH:9][CH2:8][CH2:7][NH:6][C@H:3]([CH2:4][OH:5])[CH2:2][CH3:1])[CH2:13][OH:14]

Participants

4

Reactant 1

HCID 14051Ethambutol Hydrochloride3×

Product 1

HCID 14052Ethambutol

Reagents, catalysts & solvents 2

HCID 10340Sodium CarbonateSolventHCID 14798Sodium HydroxideSolvent

Procedure

Ethambutol Dihydrochloride (ETB) is obtained from MP Biomedicals (Aurora, Ohio). ETB (7 grams) are dissolved in 100 mL of a saturated solution of sodium carbonate in 5M NaOH. The solution is stirred for 10 minutes and the free based ETB is extracted with three volumes of chloroform. The solution is dried over sodium sulfate. After filtration, the chloroform is removed by rotary evaporation. Ethambutol is represented in the structure below (a).

Workup

  1. extractionis extracted with three volumes of chloroform
  2. dry with materialThe solution is dried over sodium sulfate
  3. filtrationAfter filtration
  4. customthe chloroform is removed by rotary evaporation

Sources & evidence

ORD record
ord-bc6a8db3687a4cab96373542461f07a9
Source dataset
uspto-grants-2012_02
Patent number
US08119840B2

Linked notes

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