2-(2,5-difluorophenyl)-1-(7-iodo-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl)ethanone → 2-(2,5-Difluorophenyl)-1-{7-[4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl}ethanone

HRID 164502

Reaction equation

HRID 164502 reaction equation
[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:11])[N:12]2[c:13]3[c:14]([n:18][cH:19][c:20]([I:22])[cH:21]3)[NH:15][CH2:16][CH2:17]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[N:23]1([CH:28]2[CH2:29][CH2:30][N:31]([C:34](=[O:35])[c:36]3[cH:37][cH:38][c:39]([B:42]4[O:43][C:44]([CH3:45])([CH3:46])[C:47]([CH3:48])([CH3:49])[O:50]4)[cH:40][cH:41]3)[CH2:32][CH2:33]2)[CH2:24][CH2:25][CH2:26][CH2:27]1>>[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:11])[N:12]2[c:13]3[c:14]([n:18][cH:19][c:20](-[c:39]4[cH:38][cH:37][c:36]([C:34]([N:31]5[CH2:30][CH2:29][CH:28]([N:23]6[CH2:24][CH2:25][CH2:26][CH2:27]6)[CH2:33][CH2:32]5)=[O:35])[cH:41][cH:40]4)[cH:21]3)[NH:15][CH2:16][CH2:17]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 578860692-(2,5-difluorophenyl)-1-(7-iodo-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl)ethanoneHCID 57886103[4-(Pyrrolidin-1-yl)piperidin-1-yl][4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanone

Product 1

HCID 578859612-(2,5-Difluorophenyl)-1-{7-[4-(4-(pyrrolidin-1-yl)piperidine-1-carbonyl)phenyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl}ethanone

Sources & evidence

ORD record
ord-0313b25813394b0b87d2444cc10926fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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