2-(2,2-Dimethyl-1,3-dioxan-5-yl)ethanol → 2-(((4-(2-(2,2-Dimethyl-1,3-dioxan-5-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 1645582

Reaction equation

HRID 1645582 reaction equation
[Na:1].COC1OCC([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[CH3:31][C:32]1([CH3:41])[O:37][CH2:36][CH:35]([CH2:38]CO)[CH2:34][O:33]1>>[Na:1].[CH3:31][C:32]1([CH3:41])[O:37][CH2:36][CH:35]([CH2:38][CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[CH2:34][O:33]1

Participants

3

Reactant 2

HCID 118160112-(2,2-Dimethyl-1,3-dioxan-5-yl)ethanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667758552-(((4-(2-(2,2-Dimethyl-1,3-dioxan-5-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 2%

Procedure

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 2-(2,2-dimethyl-1,3-dioxan-5-yl)ethanol obtained in the step (28a) to obtain the title compound (58 mg, total yield: 2.0%) as a light yellow solid.

Workup

  1. customobtained in the step (28a)

Sources & evidence

ORD record
ord-204a784eaa374d44828531c6683fcdf5
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Linked notes

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