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HCID 9956704, compound → HCID 178446367, compound

HRID 1645795
Notes
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Reaction equation

HRID 1645795 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:18])=[O:17])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:42])[NH2:41]>C(O)C.O>[OH2:2].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:17])=[O:18])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:41])[NH2:42]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 9956704HCID 9956704, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178446367HCID 178446367, compoundYield 179.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

In a solution of ethanol (19.5 ml) and water (1.2 ml) was dissolved (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid (7.80 g) and L-arginine (2.84 g) with stirring at 40° C. Insoluble materials (e.g. trash) were collected by filtration and washed with a mixture of ethanol (7 ml) and water (1.3 ml). After combining the filtrate and washing, the mixture was allowed to stand at room temperature, and the precipitated crystals were collected by filtration to obtain 9.80 g of L-arginine (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid monohydrate.

Workup

  1. filtrationInsoluble materials (e.g. trash) were collected by filtration
  2. washwashed with a mixture of ethanol (7 ml) and water (1.3 ml)
  3. washwashing
  4. customto stand at room temperature
  5. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-90bfc5007a644f338e3d75f3412f9c95
Source dataset
uspto-grants-1993_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05177069

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes