1-oxo-2,3-dihydro-1H-indene-5-carbonitrile → 1-hydroxy-2,3-dihydro-1H-indene-5-carbonitrile

HRID 1646610Notes

Reaction equation

HRID 1646610 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6]2)#[N:2]>CCCCCC>[OH:12][CH:8]1[C:9]2[C:5](=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 3128961-oxo-2,3-dihydro-1H-indene-5-carbonitrile

Product 1

HCID 145153231-hydroxy-2,3-dihydro-1H-indene-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The operation is carried out as in preparation 10, starting with 5-cyano-1-indanone (1.93 g), the extracted residue is taken up in 20 ml of hexane, with agitation for one hour. After filtering, the filtrate is dried at 45° C. under reduced pressure and 1.92 g is obtained,

Workup

  1. customThe operation is carried out as in preparation 10
  2. filtrationAfter filtering
  3. customthe filtrate is dried at 45° C. under reduced pressure
  4. custom1.92 g is obtained

Sources & evidence

ORD record
ord-2eae400e965f4daf84e7cb16d725c5d4
Source dataset
uspto-grants-1993_01
Patent number
US05180741

Reaction notes

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