8-Methoxy-1,2-dihydro-benzo[f]chromen-3-one → 1,2-Dihydro-8-hydroxy-3H-naphtho[2,1-b]pyran-3-one
Reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[C:13]1[CH2:12][CH2:11][C:10](=[O:17])[O:9][C:8]=1[CH:7]=[CH:6]2>C(O)C.C(OCC)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[C:13]1[CH2:12][CH2:11][C:10](=[O:17])[O:9][C:8]=1[CH:7]=[CH:6]2Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Starting with 4.84 g (21.2 mmol) of 1,2-dihydro-8-methoxy-3H-naphtho[2,1-b]pyran-3-one from the preceding example, the title compound (3.19 g; 70.3%) was obtained as an off-white solid, mp 189°-199° C. (recrystallized from ethanol-ethyl acetate), using the procedure of example 221.
Sources & evidence
- ORD record
- ord-b3daf2a566634db9a17287ba61565e02
- Source dataset
- uspto-grants-1995_07
- Patent number
- US05434186
Reaction notes
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