HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (dimethylamino)propanedioate → 5,6-Dihydro-N,N-dimethyl-4H-pyrrolo(3,2,1ij)quinolin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (dimethylamino)propanedioate | HCID 2801725 | — |
| Reactant | tert-Butyl 4-(bromomethyl)-1H-benzo[d]imidazole-1-carboxylate | HCID 15744964 | — |
| Solvent | Ether tetrahydrofuran | HCID 21868444 | — |
| Product | 5,6-Dihydro-N,N-dimethyl-4H-pyrrolo(3,2,1ij)quinolin-5-amine | HCID 11469718 | — |
Reaction Steps
This compound was prepared by following the procedure of Example 18, but substituting methyl 7-(bromomethyl)-1H-indole-1-carboxylate for t-butyl 4-(bromomethyl) -1 H-benzimidazole-1-carboxylate and diethyl (dimethylamino)malonate for diethyl (dipropylamino) malonate. The bulk of the product was converted to the maleate salt, mp 114°-115° C. from THF/ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05436240 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-919b76de78dd4f969d27b23258461909 |
| Source note | uspto-grants-1995_07 |