Temazepam acetate → Temazepam

HRID 1648727

Reaction equation

HRID 1648727 reaction equation
C([O:4][CH:5]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:8]=2[N:7]([CH3:23])[C:6]1=[O:24])(=O)C.C(C1N=C(C2C=CC=CC=2Cl)C2C=CC(C(F)(F)F)=CC=2N(C)C1=O)(=O)C1C=CC=CC=1>>[CH3:23][N:7]1[C:6](=[O:24])[CH:5]([OH:4])[N:11]=[C:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:9]2[CH:18]=[C:19]([Cl:22])[CH:20]=[CH:21][C:8]1=2

Participants

3

Reactant 2

HCID 86793Temazepam acetateHCID 204816223-benzoyl-5-(o-chlorophenyl)-1,3-dihydro-1-methyl-8-trifluoromethyl-2H-1,4-benzodiazepine-2-one

Product 1

HCID 5391Temazepam

Procedure

When the above procedure is carried out and in place of 205 g. of O-acetyl temazepam there is used a corresponding quantity of 3-benzoyl-5-(o-chlorophenyl)-1,3-dihydro-1-methyl-8-trifluoromethyl-2H-1,4-benzodiazepine-2-one or 1,3-dihydro-1-methyl-7-nitro-3-phenacetyl-5-(p-trifluoromethylphenyl)-2H-1,4-benzodiazepine-2-one, there is obtained the corresponding 5-(o-chlorophenyl)-7-trifluoromethyl and 5-(p-trifluoromethylphenyl)-7-nitro analog of temazepam, respectively, in high yield and purity.

Sources & evidence

ORD record
ord-db189cbde28f4d8c80cc540122bd0a39
Source dataset
uspto-grants-1983_11
Patent number
US04412952

Linked notes

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