HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 2-ethylidene-4-chloro-3-oxobutyrate | HCID 54518096 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Aminothiazol-4-yl)-1-propencarboxylic acid ethyl ester | HCID 54404371 | — |
Reaction Steps
to a solution of 190 g of the product of example 81 in 400 ml tetrahydrofuran were added first a solution of 82 g sodium acetate in 150 ml of water and then 76 g thiourea. The solution was stirred at room temperature for 20 hours, then the THF was distilled off and acetic acid ethyl ester was added to the residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04416880 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-9b4705d37edf4c80b2ad9f87b172ad31 |
| Source note | uspto-grants-1983_11 |