Potassium cyanate → N-(2,6-difluorophenylsulphonyl)urea
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH-:12])(=[O:11])=[O:10].[O-:13][C:14]#[N:15].[K+]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:14]([NH2:15])=[O:13])(=[O:10])=[O:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2,6-Difluorophenylsulphonylamide in an amount of 9.65 g and 6.5 g of potassium cyanate in 100 ml of ethanol are refluxed for 3 hours. After dilution with water and filtration while hot the solution is acidified with 5 ml of conc. hydrochloric acid. The desired N-(2,6-difluorophenylsulphonyl)urea is obtained in a yield of 10.0 g; melting point 198° C. (decomp.)
Workup
- filtrationAfter dilution with water and filtration while hot the solution
Sources & evidence
- ORD record
- ord-abf75c66161943cf801083107823cad5
- Source dataset
- uspto-grants-1990_05
- Patent number
- US04927452
Reaction notes
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