2-Pyrazoline → 1-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

HRID 1650992

Reaction equation

HRID 1650992 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([NH2:15])=[O:14])(=[O:11])=[O:10].[NH:16]1[CH2:20][CH2:19][CH:18]=N1>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[S:9]([NH:12][C:13]([N:15]1[CH2:18][CH2:19][CH:20]=[N:16]1)=[O:14])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 669622-PyrazolineHCID 53937098N-(2,6-difluorophenylsulphonyl)urea

Product 1

HCID 230507491-(2,6-Difluorophenylsulphonylcarbamoyl)-2-pyrazoline

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N-(2,6-difluorophenylsulphonyl)urea in an amount of 2.36 and 1.40 g of 2-pyrazoline in 20 ml of dioxane are refluxed for 4 hours. After evaporation of the solvent at reduced pressure, the remaining solid is dissolved in 20 ml of water. This solution is filtrated and acidified with conc. hydrochloric acid. The precipitate is sucked off, washed with water and dried, yielding the title product, viz. 1-(2,6-difluorophenylsulphonylcarbamoyl)-2-pyrazoline in a yield of 1.87 g; melting point 183° C.

Workup

  1. customAfter evaporation of the solvent at reduced pressure
  2. dissolutionthe remaining solid is dissolved in 20 ml of water
  3. filtrationThis solution is filtrated
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-b18fa86a7df846fa805fdd7829ec0e5a
Source dataset
uspto-grants-1990_05
Patent number
US04927452

Linked notes

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