Maleic Acid → HCID 67870636, compound

HRID 1651562Notes

Reaction equation

HRID 1651562 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([NH2:21])=[O:20])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]\[C:31]([OH:33])=[O:32].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([NH2:21])=[O:20])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 150558684-[4-[(4-Chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanamide

Product 1

HCID 67870636HCID 67870636, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.38 g (0.98 mmol) of the amide obtained in Example 29 was dissolved in 3 ml of ethanol, and 0.11 g (0.98 mmol) of maleic acid was added. The precipitated white crystals were recrystallized from ethyl acetate to give 0.35 g (71%) of 4-[4-[(4-chlorophenyl)-2-pyridylmethoxy]-1-piperidyl]butanamide maleate.

Workup

  1. customThe precipitated white crystals were recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-fc152e1eeda44418a9e073e48c92ddf4
Source dataset
uspto-grants-1990_05
Patent number
US04929618

Reaction notes

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