2-Butyl isothiocyanate → 1-(3-Chloro-2-methylphenyl)-4-(1-methylpropyl)thiosemicarbazide

HRID 1654069

Reaction equation

HRID 1654069 reaction equation
[CH:1]([N:5]=[C:6]=[S:7])([CH2:3][CH3:4])[CH3:2].[Cl:8][C:9]1[C:10]([CH3:17])=[C:11]([NH:15][NH2:16])[CH:12]=[CH:13][CH:14]=1>C1(C)C=CC=CC=1>[Cl:8][C:9]1[C:10]([CH3:17])=[C:11]([NH:15][NH:16][C:6]([NH:5][CH:1]([CH3:2])[CH2:3][CH3:4])=[S:7])[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 781512-Butyl isothiocyanateHCID 702863(3-Chloro-2-methylphenyl)hydrazine

Product 1

HCID 200795151-(3-Chloro-2-methylphenyl)-4-(1-methylpropyl)thiosemicarbazide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.44 g (10 mmole) of sec-butyl isothiocyanate were added to 1.56 g (10 mmole) of 3-chloro-2-methylphenyl hydrazine dissolved in 120 ml of toluene, and the mixture was refluxed for 2 hours and then evaporated. The remanence was stirred with a small amount of hexane, separated by filtration and dried.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. customevaporated
  3. customseparated by filtration
  4. customdried

Sources & evidence

ORD record
ord-9f0ca789e649440ebae0831a8fd3777f
Source dataset
uspto-grants-1995_04
Patent number
US05405857

Linked notes

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