Ammonia → HCID 178510064, compound
Reaction equation
[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)=S)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:27]>>[CH2:1]([O:8][C:9]1[C:10]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)=[NH:27])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
To a stirring suspension of N-(3-benzyloxy-2-pyridyl)-N'-(4-cyanophenyl)thiourea (2 g, 0.0055 mol) in ammonia-saturated methanol (40 ml) was added yellow mercuric oxide (3 g, 0.014 mol). Stirring was continued for 20 h, then the mixture filtered through celite, and the solid washed several times with chloroform. The filtrate was evaporated to a white solid, which was triturated with ether. Yield 1.12 g (59%), m.p. 173°-175 ° C.
Workup
- filtrationthe mixture filtered through celite
- washthe solid washed several times with chloroform
- customThe filtrate was evaporated to a white solid, which
- customwas triturated with ether