N-bromobutanimide → Ethyl 2-(bromomethyl)pyridine-3-carboxylate

HRID 1655583

Reaction equation

HRID 1655583 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:13]N1C(=O)CCC1=O.C(OOCC1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:13][CH2:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 67184N-bromobutanimideHCID 74401Ethyl 2-methylnicotinateHCID 11229634Benzyl Peroxide

Product 1

HCID 825758Ethyl 2-(bromomethyl)pyridine-3-carboxylate

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Ethyl 2-methylpyridine-3-carboxylate is refluxed with N-bromosuccinimide in carbon tetrachloride with 1% equivalent dibenzyl peroxide to give the title compound.

Sources & evidence

ORD record
ord-c011fa5b18104630a033a94e85d9f287
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Linked notes

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