Water → Methyl 3-amino-2-methyl-6-methylthiobenzoate

HRID 1655804

Reaction equation

HRID 1655804 reaction equation
O.O.O.O.O.O.O.O.O.[S-2:10].[Na+].[Na+].O.[NH2:14][C:15]1[C:16]([CH3:28])=[C:17]([C:22](SC#N)=[CH:23][CH:24]=1)[C:18]([O:20][CH3:21])=O.[CH3:29]I>C(O)C>[NH2:14][C:15]1[C:16]([CH3:28])=[C:17]([C:22]([CH3:29])=[CH:23][CH:24]=1)[C:18]([O:20][CH3:21])=[S:10]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 73972Sodium sulfide nonahydrateHCID 14801188Methyl 3-amino-2-methyl-6-thiocyanatobenzoate

Product 1

HCID 54391819Methyl 3-amino-2-methyl-6-methylthiobenzoateYield 104.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution comprising 39.5 g of sodium sulfide nonahydrate and 110 ml of water, a solution comprising 32.9 g of methyl 3-amino-2-methyl-6-thiocyanobenzoate and 300 ml of ethanol, was dropwise added. The mixture was stirred at room temperature for 1.5 hours, and then 24 g of methyl iodide was dropwise added thereto under cooling with ice. The mixture was stirred at room temperature for 2 hours and then, concentrated under reduced pressure. A saturated sodium chloride aqueous solution was added thereto, and the mixture was extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off to obtain 30.1 g of the desired product. Oily substance.

Workup

  1. additionwas dropwise added
  2. temperatureunder cooling with ice
  3. stirringThe mixture was stirred at room temperature for 2 hours
  4. concentrationconcentrated under reduced pressure
  5. additionA saturated sodium chloride aqueous solution was added
  6. extractionthe mixture was extracted with chloroform
  7. dry with materialThe chloroform layer was dried over anhydrous sodium sulfate
  8. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-51109b9ee09446f59db9516630768ff3
Source dataset
uspto-grants-1993_10
Patent number
USRE034408

Linked notes

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