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Ethanol → HCID 7035705, compound

HRID 1656326
Notes
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Reaction equation

HRID 1656326 reaction equation
[CH2:1](O)[CH3:2].S(=O)(=O)(O)O.[C:9]([NH:17][C@H:18]([C:22]([OH:24])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:9]([NH:17][C@H:18]([C:22]([O:24][CH2:1][CH3:2])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 730290(2S)-3-methyl-2-(phenylformamido)butanoic acid

Product 1

HCID 7035705HCID 7035705, compoundYield 71%

Procedure

Dissolve in 100 ml of ethanol 0.045 mol (10 g) of N-benzoylvaline obtained in the preceding Step, add 5 ml of concentrated sulphuric acid, then heat at reflux for 24 hours. Evaporate to dryness, take up in ether, wash with water then with a 10% potassium bicarbonate solution, dry, filter and evaporate to dryness. Ethyl N-benzoylvalinate is obtained.

Workup

  1. customobtained in the preceding Step
On this pageParticipantsProcedureWorkupSources & evidenceReaction notes
temperature
heat
  • temperatureat reflux for 24 hours
  • customEvaporate to dryness
  • washwash with water
  • dry with materialwith a 10% potassium bicarbonate solution, dry
  • filtrationfilter
  • customevaporate to dryness

    • Sources & evidence

    ORD record
    ord-f32974852f14475aa494efe18e9dd3d6
    Source dataset
    uspto-grants-1993_10
    DOI
    10.6084/m9.figshare.5104873.v1
    Patent number
    US05254548

    Reaction notes

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