Sulfuric Acid → 2-Methyl-1,1,1,3-tetrafluoro-2-propanol
Reaction equation
[CH3:1][CH:2]([CH2:7][F:8])[C:3]([F:6])([F:5])[F:4].S(=O)(=O)(O)[OH:10]>O>[CH3:1][C:2]([OH:10])([CH2:7][F:8])[C:3]([F:6])([F:5])[F:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As another example, 2-methyl-1,1,1,3-tetrafluoro-2-propanol may be prepared by reacting commercially available methacrylic acid with hydrogen fluoride to form 2-methyl-3-fluoropropanoic acid which may then be fluorinated to form 2-methyl-1,1,1,3-tetrafluoropropane. The 2-methyl-1,1,1,3-tetrafluoropropane may then be dehydrogenated and reacted with sulfuric acid and then water to form 2-methyl-1,1,1,3-tetrafluoro-2-propanol.
Sources & evidence
- ORD record
- ord-45450f49defa412ea1c2c77563c5373f
- Source dataset
- uspto-grants-1993_10
- Patent number
- US05254755
Reaction notes
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