1-(3-Chlorophenyl)piperazine → HCID 12414808, compound

HRID 1657404

Reaction equation

HRID 1657404 reaction equation
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 46254083-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 12414808HCID 12414808, compoundYield 34.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2.4 g of 3-(2-chloroethyl)-2,6-dimethy-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed with heating for 30 hours. The reaction mixture was then treated in the same manner as in Example 1, and the obtained crude crystals were recrystallized from isopropyl alcohol to give 1.4 g of the desired compound as pale yellow needles, m.p. 116.5° - 117.5°C.

Workup

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. additionThe reaction mixture was then treated in the same manner as in Example 1
  4. customthe obtained crude crystals
  5. customwere recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-cacede88fdc148cc8f70e8a89c0ca45c
Source dataset
uspto-grants-1976_06
Patent number
US03960863

Linked notes

Loading…