Chloroacetyl chloride → 2-Chloro-N-(2-methyl-4-sulphamoylphenyl)-acetamide

Reaction equation

[CH3:1][C:2]1[CH:8]=[C:7]([S:9](=[O:12])(=[O:11])[NH2:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:13][CH2:14][C:15]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([S:9](=[O:12])(=[O:11])[NH2:10])=[CH:8][C:2]=1[CH3:1])=[O:16]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 1430374-Amino-3-methylbenzene-1-sulfonamide

Product 1

HCID 215288492-Chloro-N-(2-methyl-4-sulphamoylphenyl)-acetamide

Procedure

2-methyl-4-sulphamoylaniline (18,6 g) and α-chloroacetyl chloride (30g) were refluxed together 30 min. and the mixture worked up as in Example 2(a) to yield 11 g, m.p. 193°-194°

Workup

customto yield 11 g, m.p. 193°-194°

Sources & evidence

ORD record: ord-af1623bdbf9c4a9ea3f1a88efd2e675b
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03963706

Reaction notes

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