Thionyl Chloride → beta-(2'-Chloro-4-biphenylyl)propionyl chloride

HRID 1659067Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=1.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([Cl:21])=[O:18])=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 1394276beta-(2'-Chloro-4-biphenylyl)propionic acid

Product 1

HCID 21526230beta-(2'-Chloro-4-biphenylyl)propionyl chloride

Conditions

Temperature: 60 °C

Procedure

β-(2'-chloro-4-biphenylyl)propionic acid (26 g.) is treated with thionyl chloride (18 g.) at 0°-5°C. After 10 mins the temperature is raised to 60°C for 30 mins, then the residue is distilled at 0.05 mm to give β-(2'-chloro-4-biphenylyl)propionyl chloride.

Workup

distillationthe residue is distilled at 0.05 mm

Sources & evidence

ORD record: ord-1cf2ddcaced44d57af0b1b597587984a
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03966801

Reaction notes

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