1-(1-Piperidinylcarbonyl)piperazine → HCID 21527121, compound

HRID 1659097

Reaction equation

HRID 1659097 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:16]1([C:22]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[N:16]1([C:22]([N:24]2[CH2:25][CH2:26][N:27]([C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][N:3]=3)[CH2:28][CH2:29]2)=[O:23])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 10950151-(1-Piperidinylcarbonyl)piperazineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 21527121HCID 21527121, compound

Procedure

In like manner, 1-chloro-6,7-diethoxyisoquinoline and 1-(piperidinocarbonyl)piperazine react to afford 1-(4-piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline, while 4-chloro-6,7-dimethoxyquinazoline and 1-(piperidinocarbonyl)piperazine react to afford 4-(4-piperidinocarbonyl-1-piperazinyl)-6,7-dimethoxyquinazoline respectively. The latter compound is, of course, identical in every respect with the product of Example V.

Sources & evidence

ORD record
ord-8a20e72eb138456abaccf1ead34f882f
Source dataset
uspto-grants-1976_06
Patent number
US03966936

Linked notes

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