Acetic Anhydride → Quinezamide

Reaction equation

[NH2:1][C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[CH3:15].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[NH:1]([C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[CH3:15])[C:16]([CH3:17])=[O:18]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 20560264HCID 20560264, compound

Product 1

HCID 3052771QuinezamideYield 89%

Procedure

1-Amino-5-methylpyrazolo[1,5-c]quinazoline is treated with acetic anhydride as described in Example 5 to give 1-acetamino-5-methylpyrazolo[1,5-c]quinazoline. M.p.: 258°-260° C. Yield: 89%.

Sources & evidence

ORD record: ord-1b9be80e98ac4a64b1616b866c2c7d9c
Source dataset: uspto-grants-1981_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04303660

Reaction notes

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