1-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one → Methyl 1-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylate

HRID 16598

Reaction equation

HRID 16598 reaction equation
[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].C([O:18][C:19]([NH:21][CH2:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:29][C:30]2([C:34]([O:36][CH3:37])=[O:35])[CH2:33][CH2:32][CH2:31]2)[CH2:25][CH2:24]1)=O)(C)(C)C>>[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([C:19]([NH:21][CH2:22][CH:23]2[CH2:24][CH2:25][N:26]([CH2:29][C:30]3([C:34]([O:36][CH3:37])=[O:35])[CH2:33][CH2:32][CH2:31]3)[CH2:27][CH2:28]2)=[O:18])[C:5]1=[O:13])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 16535801-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 67233391Methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]cyclobutanecarboxylate

Product 1

HCID 68584360Methyl 1-{[4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylate

Procedure

The title compound was prepared according to the procedure described in Step 6 of Example 1 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}piperidin-1-yl)methyl]cyclobutanecarboxylate (step 2 of Example 7).

Sources & evidence

ORD record
ord-0e4870f835fa4bc58a380452a03391ad
Source dataset
uspto-grants-2010_06
Patent number
US07737163B2

Linked notes

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