HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 166Generated: October 24, 2026
2-Chloro-4-aminopyrimidine → (3-(2-Chloropyrimidin-4-ylamino)-4-fluorophenyl)methanol
https://huagongshe.com/en/reaction/166
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-4-aminopyrimidine | HCID 345752 | — |
| Reactant | 3-Bromo-4-fluorobenzyl Alcohol | HCID 2773351 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3-(2-Chloropyrimidin-4-ylamino)-4-fluorophenyl)methanol | HCID 59817845 | 0% |
Reaction Steps
diacetoxypalladium (8.67 mg, 0.04 mmol) was added to 2-chloropyrimidin-4-amine (100 mg, 0.77 mmol), (3-bromo-4-fluorophenyl)methanol (158 mg, 0.77 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (53.6 mg, 0.09 mmol) and cesium carbonate (503 mg, 1.54 mmol) in 1,4-dioxane (4 mL) . The resulting suspension was stirred at 150 °C in the microwave for 30 minutes. None of the desired material was visible by LCMS. Reaction abandoned.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-99e222e4d9a34b6bb8073fb91a88f0f7 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
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