Ammonia → 2-[(aminocarbamothioyl)amino]acetamide
Reaction equation
C([O:3][C:4]([CH2:6][NH:7][C:8](=[S:11])[NH:9][NH2:10])=O)C.[NH3:12]>C(O)C>[C:4]([CH2:6][NH:7][C:8](=[S:11])[NH:9][NH2:10])(=[O:3])[NH2:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
4-Ethoxycarbonylmethyl-thiosemicarbazide (8.33 g) (GANTE and LANTSCH, Chem. Ber., 97, 989 (1964)) are suspended in a saturated solution (250 cc) of ammonia in ethanol, and the reaction mixture is stirred at 25° C. for 22 hours. The insoluble matter is filtered off and washed with alcohol (2×25 cc) and ether (2×50 cc); after drying, 4-carbamylmethyl-thiosemicarbazide (6.2 g), m.p.=188° C., is obtained.
Workup
- filtrationThe insoluble matter is filtered off
- washwashed with alcohol (2×25 cc) and ether (2×50 cc)
- customafter drying
Sources & evidence
- ORD record
- ord-0cd905d13c3f4f84aa4123c2b62c18d7
- Source dataset
- uspto-grants-1981_12
- Patent number
- US04307116
Reaction notes
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