Methyl isothiocyanate → HCID 178432727, compound
Reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]([NH:10][NH2:11])=O)=[C:5]([CH3:7])[N:6]=1.[CH3:12][N:13]=[C:14]=[S:15]>C(O)C>[CH3:1][C:2]1[S:3][C:4]([C:8]2[N:13]([CH3:12])[C:14]([SH:15])=[N:11][N:10]=2)=[C:5]([CH3:7])[N:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a 2,4-dimethylthiazole-5-carbohydrazide (Prep26, 23 g, 0.13 mol) in ethanol (100 ml), methyl isothiocyanate (49.1 g, 0.67 mol) was added. The mixture was refluxed overnight. Then the ethanol was partially removed under vacuum and the residue was filtered. The solid was dried under vacuum to afford 14 g of the title compound (y=46%).
Workup
- temperatureThe mixture was refluxed overnight
- customThen the ethanol was partially removed under vacuum
- filtrationthe residue was filtered
- customThe solid was dried under vacuum
Sources & evidence
- ORD record
- ord-6a53f4a191fd4b9688199acb32574d83
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08030322B2
Reaction notes
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