Sodium Hydroxide → HCID 57654546, compound
Reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:23])[CH:7]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[CH:16]2)C(OCC)=O)C>CO>[N:19]1[C:20]2[C:15](=[CH:14][C:13]([CH2:7][C:6]([OH:23])=[O:5])=[CH:22][CH:21]=2)[CH:16]=[N:17][CH:18]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium hydroxide [2M] (0.77 mL) was added to a solution of 2-quinazolin-6-yl-malonic acid diethyl ester (0.20 g, 0.77 mmol) in methanol (10 mL) and stirred at room temperature for several hours. The reaction was evaporated, ethyl acetate was added and then 1N HCl was added dropwise until the compound went into the organic layer. The organic layer was evaporated to give 0.123 g (85%) of quinazolin-6-yl -acetic acid.
Workup
- customThe reaction was evaporated
- additionethyl acetate was added
- addition1N HCl was added dropwise until the compound
- customThe organic layer was evaporated
Sources & evidence
- ORD record
- ord-5d9c062cf693418fbeeef7c2bba68da6
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08030305B2
Reaction notes
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