3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → 2-{[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]amino}-N,N-dimethylacetamide
Reaction equation
Cl[C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].FC(F)(F)C(O)=O.[NH2:28][CH2:29][C:30]([N:32]([CH3:34])[CH3:33])=[O:31]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3](=[O:12])[C:2]2([NH:28][CH2:29][C:30]([N:32]([CH3:34])[CH3:33])=[O:31])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]Participants
3
Procedure
With 2.01 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and the compound obtained in Step 62-2 (7.81 mmol, crude form) as starting material, 1.91 g of the title compound (colorless powder) was obtained by a similar method to Step 4-2.
Sources & evidence
- ORD record
- ord-b2047395f7704c3c95b2d22ad0824759
- Source dataset
- uspto-grants-2011_10