5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione → 3-(1,3-benzodioxol-4-yl)-3-hydroxy-5-(trifluoromethoxy)-1,3-dihydro-2H-indol-2-one

HRID 1662798

Reaction equation

HRID 1662798 reaction equation
Br[C:2]1[C:10]2[O:9][CH2:8][O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:11][C:12]([F:26])([F:25])[O:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[C:17]2=[O:24]>>[O:7]1[C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:17]3([OH:24])[C:16]4[C:20](=[CH:21][CH:22]=[C:14]([O:13][C:12]([F:11])([F:26])[F:25])[CH:15]=4)[NH:19][C:18]3=[O:23])[C:10]=2[O:9][CH2:8]1

Participants

3

Reactant 2

HCID 27327525-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dioneHCID 27761894-Bromo-1,3-benzodioxole

Product 1

HCID 674294733-(1,3-benzodioxol-4-yl)-3-hydroxy-5-(trifluoromethoxy)-1,3-dihydro-2H-indol-2-oneYield 46.9%

Procedure

With 7.80 g of 4-bromo-1,3-benzodioxol and 2.30 g of 5-trifluoromethoxyisatin as starting materials, 1.65 g of the title compound was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-4ae2c9fdcdef4014bb2f665ba2c58394
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Linked notes

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