2,3-Dihydroxybutanedioic Acid → HCID 178418492, compound

HRID 1663

Reaction equation

HRID 1663 reaction equation
[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28]3[CH:33]=[CH:32][C:31]([CH2:34][N:35]([CH3:37])[CH3:36])=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:20])=[CH:14][CH:13]=1.C(OCC)C>C(O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:23][CH2:24][C@H:25]([C:28]3[CH:29]=[CH:30][C:31]([CH2:34][N:35]([CH3:36])[CH3:37])=[CH:32][CH:33]=3)[CH2:26][CH2:27]2)=[O:20])=[CH:14][CH:13]=1.[C:6]([CH:4]([CH:2]([C:1]([O-:10])=[O:9])[OH:3])[OH:5])([O-:8])=[O:7]

Participants

5

Reactant 3

HCID 8752,3-Dihydroxybutanedioic AcidHCID 3283Diethyl EtherHCID 178418347HCID 178418347, compound

Product 1

HCID 178418492HCID 178418492, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

First 0.15 g (0.001 mol) of anhydrous tartaric acid and then 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol are dissolved in 7 ml of absolute ethanol. Diethyl ether is then added to the clear solution until it becomes slightly cloudy and it is then left to stand for 8 hours at +4° C. The crystalline product precipitated is suction filtered, washed with diethyl ether and dried.

Workup

  1. waitit is then left
  2. customThe crystalline product precipitated
  3. filtrationfiltered
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-55aacc7a80b0419cab9d2c65fa6adadb
Source dataset
uspto-grants-1998_03
Patent number
US05726205

Linked notes

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