Isatoic Anhydride → 1-(6-Oxo-1,6-dihydro-pyridin-3-ylmethyl)-1H-benzo[d][1,3]oxazine-2,4-dione

Reaction equation

[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6][C:5](=[O:12])[O:4][C:2]2=[O:3].O[CH2:14][C:15]1[CH:16]=[CH:17][C:18](=[O:21])[NH:19][CH:20]=1>>[O:21]=[C:18]1[NH:19][CH:20]=[C:15]([CH2:14][N:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=3[C:2](=[O:3])[O:4][C:5]2=[O:12])[CH:16]=[CH:17]1

Participants

Reactant 2

HCID 8359Isatoic Anhydride

HCID 120185765-(hydroxymethyl)pyridin-2(1H)-one

Product 1

HCID 589899141-(6-Oxo-1,6-dihydro-pyridin-3-ylmethyl)-1H-benzo[d][1,3]oxazine-2,4-dione

Procedure

Prepared by a similar procedure as described for preparation 7B, starting from isatoic anhydride and 5-hydroxymethyl-1H-pyridin-2-one (prepared as described in WO 01/77078 A1).

Workup

customPrepared by a similar procedure

Sources & evidence

ORD record: ord-75b08b7320db43de9b9ee168d3325713
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08034811B2

Reaction notes

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