3-Azaisatoic anhydride → 1-(6-Oxo-1,6-dihydro-pyridin-3-ylmethyl)-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione
Reaction equation
[NH:1]1[C:6]2[N:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4](=[O:11])[O:3][C:2]1=[O:12].O[CH2:14][C:15]1[CH:16]=[CH:17][C:18](=[O:21])[NH:19][CH:20]=1>>[O:21]=[C:18]1[NH:19][CH:20]=[C:15]([CH2:14][N:1]2[C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:11])[O:3][C:2]2=[O:12])[CH:16]=[CH:17]1Participants
3
Procedure
May be prepared by a similar procedure as described for preparation 7B, starting from 1H-pyrido[2,3-d][1,3]oxazine-2,4-dione (can be prepared as described by Beckwith and Hickman in J. Chem. Soc. (C), 1968 pp 2756-2759) and 5-hydroxymethyl-1H-pyridin-2-one (prepared as described in WO 01/77078 A1).
Workup
- customMay be prepared by a similar procedure
Sources & evidence
- ORD record
- ord-f9e3edd89e2045c4b4d748eb2a5376a0