Sodium Hydroxide → 1-methyl-1H-1,2,3-triazole-5-carboxylic acid
Reaction equation
[CH3:1][N:2]1[C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][N:4]=[N:3]1.[OH-].[Na+]>CO>[CH3:1][N:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][N:4]=[N:3]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of ethyl 1-methyl-1H-1,2,3-triazole-5-carboxylate (1.15 g, 7.41 mmol) in methanol (17 mL) was added 1N sodium hydroxide (11.5 mL), and the mixture was stirred at room temperature for 1 hr. Methanol was evaporated under reduced pressure, 1N hydrochloric acid (12 mL) was added to the mixture, the precipitated crystals were collected by filtration and washed with water. The crystals were vacuum dried at 90° C. to give the title compound (148 mg, 16%) as a white powder.
Workup
- customMethanol was evaporated under reduced pressure, 1N hydrochloric acid (12 mL)
- additionwas added to the mixture
- filtrationthe precipitated crystals were collected by filtration
- washwashed with water
- customdried at 90° C.
Sources & evidence
- ORD record
- ord-8b0057b026044ab0bfd074dab529d741
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08034812B2
Reaction notes
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