Sodium Hydroxide → 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 1663675

Reaction equation

HRID 1663675 reaction equation
[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2].[OH-].[Na+]>CO>[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441049methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410503-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acidYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate (2.59 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (1.94 g, yield 81%) was obtained.

Sources & evidence

ORD record
ord-57835d67dd354669af6c4eaf6a414f26
Source dataset
uspto-grants-2011_10
Patent number
US08034812B2

Linked notes

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