Ammonia hydroxide → HCID 178446159, compound

Reaction equation

CS[C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[N:4]=1.[OH-].[NH3:19]>>[NH:19]=[C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[NH:4]1

Participants

Reactant 2

HCID 21862953Ammonia hydroxide

HCID 576002282-(methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one

Product 1

HCID 178446159HCID 178446159, compoundYield 68%

Conditions

Temperature: 100 °C

Procedure

2-(Methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one (5.0 g, 0.020 mol) was mixed with 100 ml of 28% ammonia hydroxide in a seal tube. The mixture was stirred at 100° C. for 4 days. After cooling to room temperature, the solid was filtered and dried to yield the desired product (3.0 g, 68%). LCMS calculated for C10H16N5O (M+H): 222.1. found: 222.1.

Workup

temperatureAfter cooling to room temperature
filtrationthe solid was filtered
customdried

Sources & evidence

ORD record: ord-271cc3c13b3a4a0daa091460f7943ec4
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08039478B2

Reaction notes

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