methyl 1H-indole-4-carboxylate → 1-Isopropylcarbamoyl-1H-indole-4-carboxylic acid
Reaction equation
[CH:1]([NH:4][C:5](=[O:16])NC1C=C(C=CN=1)C(O)=O)([CH3:3])[CH3:2].NC1C=C(C=CN=1)C(OCC)=O.[NH:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([C:38]([O:40]C)=[O:39])[C:32]=2[CH:31]=[CH:30]1>>[CH:1]([NH:4][C:5]([N:29]1[C:37]2[CH:36]=[CH:35][CH:34]=[C:33]([C:38]([OH:40])=[O:39])[C:32]=2[CH:31]=[CH:30]1)=[O:16])([CH3:3])[CH3:2]Participants
4
Procedure
This compound is prepared analogously to Intermediate Y by replacing ethyl 2-aminoisonicotinate in step 1 with methyl indol-4-carboxylate; [M+H]+ 247
Sources & evidence
- ORD record
- ord-470937c0265742ddac611e993c35f0d0
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08039472B2
Reaction notes
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