Potassium Hydroxide → 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid

HRID 1665238

Reaction equation

HRID 1665238 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:19]=3[F:26])=[CH:14][CH:13]=2)[CH:5]=1.[OH-].[K+]>CO>[F:26][C:19]1[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:18]=1[C:15]1[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:27])=[O:2])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 671503683-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester

Product 1

HCID 582711903-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acidYield 93.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(2′,4′,5′-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester (2.9 g, 7.79 mmol) and 2N KOH (15.6 mL, 31.2 mmol) in 140 mL MeOH were reacted as above to yield 2.6 g (93.2%) of 3-(2′,4′,5′-trifluoro-biphenyl-4-yloxymethyl)-benzoic acid. LC-MS (ES) calculated for C20H13F3O3, 358.32; found m/z 357.1 [M−H]−.

Sources & evidence

ORD record
ord-609658ca5e9d4318a596d2c7c9fcae05
Source dataset
uspto-grants-2011_10
Patent number
US08039495B2

Linked notes

Loading…