Sodium Hydroxide → 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 1667860

Reaction equation

HRID 1667860 reaction equation
[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2].[OH-].[Na+]>CO>[CH2:1]([O:3][C:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]([CH3:13])[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441049methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410503-ethoxy-1-methyl-1H-pyrazole-5-carboxylic acidYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-ethoxy-1-methyl-1H-pyrazole-5-carboxylate (2.59 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (1.94 g, yield 81%) was obtained.

Sources & evidence

ORD record
ord-ce5dc8c896ed40fb8ddb0a20742f44b0
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Linked notes

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