5-Aminovaleric acid → Methyl 5-aminopentanoate hydrochloride

5-Aminovaleric acid (7.35 g) is dissolved in methanol (50 ml), and thereto is added dropwise thionyl chloride (4.9 ml) under ice-cooling. The reaction solution is then warmed to room temperature and stirred for 17 hours. The reaction solution is concentrated under reduced pressure. The resulting residue is suspended in diethyl ether and the precipitates are collected by filtration to give methyl 5-aminovalerate hydrochloride (9.93 g).

1. temperaturecooling
2. concentrationThe reaction solution is concentrated under reduced pressure
3. filtrationthe precipitates are collected by filtration

ORD record

ord-aa88e5f4b1ca45bfa1e9bb7a8dcca652

Source dataset

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07737161B2