1-(Bromomethyl)-3-(trifluoromethoxy)benzene → 5-[4-(3-Trifluoromethoxy-benzyl)-piperazin-1-yl]-quinazoline-2,4-diamine
Reaction equation
[F:19][C:20]([O:21][c:22]1[cH:23][c:24]([CH2:25][Br:26])[cH:27][cH:28][cH:29]1)([F:30])[F:31].[N:1]1([c:7]2[c:8]3[c:9]([NH2:18])[n:10][c:11]([NH2:17])[n:12][c:13]3[cH:14][cH:15][cH:16]2)[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1>>[N:1]1([c:7]2[c:8]3[c:9]([NH2:18])[n:10][c:11]([NH2:17])[n:12][c:13]3[cH:14][cH:15][cH:16]2)[CH2:2][CH2:3][N:4]([CH2:25][c:24]2[cH:23][c:22]([O:21][C:20]([F:19])([F:30])[F:31])[cH:29][cH:28][cH:27]2)[CH2:5][CH2:6]1Participants
3
Sources & evidence
- ORD record
- ord-5fb9dae6f62a40dd966f67413fd0f8cd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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